Topological Analysis of the Type 3 Secretion System Translocon Pore Protein IpaC following Its Native Delivery to the Plasma Membrane during Infection
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Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein
Bacterial pathogens often deliver effectors into host cells using type 3 secretion systems (T3SS), the extremity of which forms a translocon that perforates the host plasma membrane. The T3SS encoded by Salmonella pathogenicity island 1 (SPI-1) is genetically associated with an acyl carrier protein, IacP, whose role has remained enigmatic. In this study, using tandem affinity purification, we i...
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ژورنال
عنوان ژورنال: mBio
سال: 2019
ISSN: 2150-7511
DOI: 10.1128/mbio.00877-19